Respiratory System

 

California Standard

 Students know how the complementary activity of major body systems provides cells with oxygen and nutrients and removes toxic waste products such as carbon dioxide.

Lecture
Lab: Spirometer
Lab: Respiration

Video Questions - Respiration

Directions for writing Respiration Lab Report - NEW
Crossword Puzzle
Review Questions NEW 2009
Figure: Lungs

I. Introduction

1. Cells need continuous supply of oxygen.  C6H12O6 + 6O2 ----- 6CO2 + 6H20 (Cellular respiration).
2. ATP is produced.
3. Excess carbon dioxide produces acid conditions that are poisonous to cells.
4. Respiratory system consists of organs that exchange gases between atmosphere and blood.
5. Organs are nose, pharynx, larynx, trachea, bronchi, and lungs.
6. Cardiovascular system transports gases between lungs and cells.
7. Upper respiratory system in nose, pharynx, larynx, and associated structures.
8. Lower respiratory system is remainder.
9. Respiration is exchanges of gases between atmosphere, blood, and cells.
10. Three primary processes:
11. Pulmonary ventilation (breathing) is inspiration (inflow) and expiration (outflow) of air between atmosphere and lungs.
12. External respiration is exchange of gases between interstitial fluids of body and external environment.
13. Internal respiration is exchange of gases between cells and fluids.
14. Respiratory and cardiovascular systems function equally. Failure of either has same effect on body: disruption of homeostasis.

II. Upper Respiratory Tract
1. Nasal cavity:

Figure - Nasal Cavity 1

Figure - Nasal Cavity 2

a. Air enters external nares (nostrils) and enters nasal cavities. The first portion, contained in the nose, is the nasal vestibule. It is separated by a nasal septum, made of hyaline cartilage.
b. Nasal cavity is lined with mucous membrane and cilia. Vestibule has coarse hair, which trap large airborne particles.
c. Three nasal conchae or turbinate bones form ridges in the cavity, which increase surface area of cavities. Superior, middle and inferior nasal conchae.
d. These bones form 3 channels: Superior, middle, and inferior meatuses.
Conchae cause turbulence in flowing air, forcing it to move in different directions.  Turbulence aids mucous membrane in cleaning air.
e. Four pairs of sinuses drain into the nose.  These openings, the paranasal sinuses,  also act as resonance chambers for sound. In addition tears drain through nasalacrimal ducts help keep cavity moist.
f. Air passes between the cavity and the pharynx (throat) through two openings called the internal nares.
g. Air is saturated with water, cleansed of particles, and warmed by blood vessels.
Cilia move mucous and dirt back towards outside of body.
h. Superior to the nasal chonchae is the olfactory region. In this region are elongated cells, which are supported by larger cells. The free ends have hair-like projections. Air brushes as it passes.

Olfactory neurons

2. Pharynx (throat) Passageway for food and air - 13 cm (5 inches). Serves as resonance chamber for sound.

a. Shows extensive growth in early embryo, forming fingerlike projections - lungs.

b. Masses of lymphatic tissue become tonsils.

c. Extends from lower portion of pharynx (internal nares) ends at larynx at glottis (opening to larynx).

d. Epiglottis is flap of skin and elastic cartilage, which covers glottis when swallowing. Epiglottis and glottis are considered part of larynx.

e. Lined with mucous membrane and composed of skeletal muscles.

f. Three portions of pharynx:\

1. nasopharynx. From internal nares to soft palate. Contains auditory (Eustachian tubes) which equalize air pressure in inner ear. Contains pharyngeal tonsil or adenoid.

2. Oropharynx lies posterior to oral cavity and extends from soft palate to hyoid bone. Contains palatine and lingual tonsils. (2 pairs) (Lingual tonsil lies at base of tongue).

3. Laryngopharynx extends downwards from hyoid bone to esophagus.

3. Larynx

Larynx

a. Glottis opens into triangular chamber, larynx or voice box.

b. Apex of triangle points forward and extends outward to thyroid cartilage (Adam's apple) - larger in males than in females.

c. Walls are composed of plates of cartilage derived from embryonic structures called the pharyngeal arches.

d. Thyroid cartilage is largest and contains 2 plates which form laryngeal prominence (Adam's apple).

e. Cricoid cartilages lie just inferior to thyroid. It is shaped like a signet ring.

f. There are 7 other cartilages called arytenoid cartilages, which are attached to vocal cords.

g. Vocal cords are at opening of glottis (space between cords). Shape of glottis can be changed to form sounds of voice.

h.There are two pairs of folds: 1. Ventricular folds (false vocal cords). These are upper. 2. Vocal folds (true vocal cords).

Vocal Cords

III. Lower Respiratory Tract

1. Below the larynx the respiratory system branches inot smaller components.
2. The trachea is a tube about 12 cm (4.5 inches) long and 2.5 cm (1 inch) in diameter. Walls are composed of alternate bands of membrane and cartilage.

a. Located anterior to esophagus.
b. Lining of trachea is pseudostratified. It consists of columnar cells that reach the surface, goblet cells, and basal cells that do not reach the luminal surface. (lumin is cavity).
c. Cartilaginous layer consists of 16 to 20 horizontal incomplete rings of hyaline cartilage.
d. Elastic cartilage and smooth muscle connect and support cartilage and open side of rings, which face esophagus for swallowing.
e. Trachea branches into left and right primary bronchi at an internal ridge called the carina. It is formed by posterior and inferior portions of last tracheal cartilage.
f. Tracheostomy is an incision made in neck just above the cricoid cartilage.
g. Carina is sensitive area associated with cough reflex.

3. Left pimary bronchus to left lung, right primary bronchus to right lung.

a. Contain incomplete rings of cartilage and lined with pseudostratifed ciliated epithelium.
b. Bronchi branch to smaller tubes called secondary (lobar) bronchi. Each goes to a lobe of lung. Left has two, the right has tree.
c. They continue to branch into teriary (segmental) bronchi. These divide into bronchioles. These branch into terminal bronchioles.
This continuous branching is called bronchial tree.
d. Cartilage disappears in bronchioles. During asthma attack smooth muscles of bronchioles go into spasm. Because of lack of supporting cartilage, spasms can close off air passageways.

4. Lungs are cone-shaped organs that fill the pleural portions of the thoracic cavity.

a. Apex of lung (upper border) projects above the collar bones (clavicles).
b. Terminal bronchioles subdivide into smaller branches - repiratory bronchioles. These brach into - alveolar ducts.
c. These terminate in alveolar sacs (2 or more alveoli). The walls of the sacs are alveoli.
d. There are approximately 300 million alveoli in both lungs.
e. Alveolar ducts, alveolar sacs, and the alveoli consist of single layer of simple squamous epithelial tissue, suitable for exchange of gases.
f. Alveolar walls are lined with 2 types of cells: squamous pulmonary epithelial cells and septal cells.
g. Squamous cells from continous lining. Septal cells are interspersed and secrete surfactant which lowers surface tension.
h. Also, alveolar macrophages remove dust particles or other debris.
i. Also present in wall are reticular and eleastic fibers.

5. Alveolar-Capillary (respiratory ) Membrane

a. Four layers which promotes exchanges of gases between alveoli and capillaries.'

1. squamous pulmonary epithelial cells, septal cells, macrophages - alveolar wall.
2. Epthelial basement membrane of alveolar wall.
3. Capillary basement membrane fused to epithelial basement membrane.
4. Endothelial cells of capillary.

b. Averages only 0.5um in thickness.
c. Lungs contain 300 million alveoli, with surface area of 70m2.

see 564 - squamuous, septal, surfactant, etc.